Runes are magical bases that summon Familiars. Runes can not be drawn next to Crystals, they can also be destroyed by enemy Familiars once its hit points have gone down to zero. There are 4 different classes of Runes
Each class is strong against one class and weak against another. Glamour is strong against Necromancy, Necromancy is strong against Sorcery, Sorcery is strong against Alchemy and Alchemy is strong against Glamour.
Each Rune can be leveled up with the cost of 100 Mana, each Rune can be leveled up to level 5 except for the Gehenna and Acheron Runes which can only level up to level 4.